Glucocorticoid Rhythm Renders Female Mice More Daring

Glucocorticoid Rhythm Renders Female Mice More Daring

Glucocorticoids, which have been implied in mood modulation, display robust diurnal oscillations in the blood. But does their circadian rhythm regulate mood swings? Ikeda et al. now identify a paracrine signaling pathway in the adrenal cortex that potentiates the daily amplitude of plasma glucocorticoids and renders female mice braver.

IFN-g Production Renders Mice More Susceptible to Helminth Infection

Informativity renders a referent more accessible: Evidence from eyetracking.

The amount of information attached to a noun phrase (henceforth, NP) has been shown to enhance accessibility and increase pronominal reference in language production. However, both the effect of information quantity on the comprehension of ambiguous pronouns and the time course of any informativity effect have been left unexplored. In two eyetracking experiments, we investigated how additional ...

Editorial: Daring to Speak Out

When we commented on the Brussels bombings in Issue 3, we did not imagine that further shocking violence would be in the forefront of our minds only a few months later. Two horrific events in recent weeks have brought tragedy to the lives of individuals and families and forced into public consciousness issues of principle which lie at their heart. The mass shootings in the early hours of Sunday...

Glucocorticoid-mediated Period2 induction delays the phase of circadian rhythm

Glucocorticoid (GC) signaling synchronizes the circadian rhythm of individual peripheral cells and induces the expression of circadian genes, including Period1 (Per1) and Period2 (Per2). However, no GC response element (GRE) has been reported in the Per2 promoter region. Here we report the molecular mechanisms of Per2 induction by GC signaling and its relevance to the regulation of circadian ti...